The National Highway Traffic Safety Administration gave the 2007 Escalade a five-star frontal crash-test rating; it hadn't done a side-impact test as of this writing. Rollover ratings were listed at three stars, which means in a single-vehicle crash the Escalade has a 22 - 24 percent chance of rolling over. That's about average for SUVs of this class. The Insurance Institute for Highway Safety has not yet rated the Escalade or any other new full-size SUV.

The Escalade comes with plenty of safety features, including stability control, rollover mitigation, antilock brakes and side curtain airbags for all three rows of seats.